Peer-reviewed journal articles 

  1. Overcoming translational barriers in modeling macular degenerations. Nolan ND, Quinn PMJ, Tsang SH. Cell Stem Cell. 2021. In Press
  2. Impaired cholesterol efflux in retinal pigment epithelium of individuals with juvenile macular degeneration. Tsai Y, Li Y, Ryu J, Su P, Cheng C, Wu W, Li Y, Quinn PMJ, Leong KW, Tsang SH. Am. J. Hum. Genet., 1–16. doi:10.1016/j.ajhg.2021.04.006.
  3. Defining phenotype, tropism, and retinal gene therapy using adeno-associated viral vectors (AAV) in new-born Brown Norway rats with a spontaneous mutation in Crb1. Boon N, Alves CH, Mulder AA, Andriessen CA, Buck TM, Quinn PMJ, Vos RM, Koster AJ; Jost CR. Wijnholds J. Int J Mol Sci. 2021 Mar 30;22(7):3563. doi: 10.3390/ijms22073563. PMID: 33808129
  4. Organoids and organ chips in ophthalmology. Manafi N, Shokri F, Achberger K, Hirayama H, Mohammadi MH, Noorizadeh F, Hong J, Liebau S, Tsuji T, Quinn PMJ*, Mashaghi A*. Ocul Surf. 2020 Nov 18;19:1-15. doi: 10.1016/j.jtos.2020.11.004. PMID: 33220469 *Co-last author
  5. PINK1/PARKIN signalling in neurodegeneration and neuroinflammation. Quinn PMJ, Moreira PI, Ambrósio AF, Alves CH. Acta Neuropathol Commun. 2020 Nov 9;8(1):189. doi: 10.1186/s40478-020-01062-w. PMID: 33168089
  6. Precision metabolome reprogramming for imprecision therapeutics in retinitis pigmentosa. Caruso S, Ryu J, Quinn PMJ, Tsang SH. J Clin Invest. 2020 Jul 13. doi: 10.1172/JCI139239. PMID: 32657778
  7. Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective. Quinn PMJ and Wijnholds J. Genes. 2019 Nov 29;10(12):987. doi: 10.3390/genes10120987. PMID: 31795518
  8. Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5. Quinn PM*, Buck TM*, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J. Stem Cell Reports. 2019 Mar 22. pii: S2213-6711(19)30087-6. doi: 10.1016/j.stemcr.2019.03.002. PMID: 30956116 *Co-first author
  9. Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype. Quinn PM, Mulder AA, Alves CH, Desrosiers M, de Vries SI, Klooster J, Dalkara D, Koster AJ, Jost CR, Wijnholds J. Hum Mol Genet. 2019 Jan 1;28(1):105-123. doi: 10.1093/hmg/ddy337. PMID: 30239717
  10. Transplantation of NTPDase2-positive Sorted Müller Glial Cells into the Mouse Retina. Hoek RM*, Quinn PM*, Hooibrink B, Wijnholds J. J Neurosci Neurosurg. 2018 Nov;1(5):122. doi: 10.31021/jnn.20181122. *Co-first author
  11. CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function. Quinn PM, Alves CH, Klooster J, Wijnholds J. Hum Mol Genet. 2018 Sep 15;27(18):3137-3153. doi: 10.1093/hmg/ddy194. PMID: 29893966
  12. NTPDase2 as a Surface Marker to Isolate Flow Cytometrically a Müller Glial Cell Enriched Population from Dissociated Neural Retinae. Hoek RM*, Quinn PM*, Alves CH, Hooibrink B, Wijnholds J. J Neurosci Neurosurg. 2018 Aug;1(4):117. doi: 0.31021/jnn.20181117. *Co-first author
  13. The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy. Quinn PM, Pellissier LP, Wijnholds J.Front Neurosci. 2017 Apr 5;11:175. doi: 10.3389/fnins.2017.00175. eCollection 2017. Review. PMID: 28424578 
  14. Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models. Pellissier LP, Quinn PM, Alves CH, Vos RM, Klooster J, Flannery JG, Heimel JA, Wijnholds J. Hum Mol Genet. 2015 Jun1;24(11):3104-18. doi: 10.1093/hmg/ddv062. Epub 2015 Feb 20. PMID: 25701872
  15. Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis. Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DM, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J. PLoS Genet. 2013;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5. PMID: 24339791

Book Chapters

  1. Production of iPS-Derived Human Retinal Organoids for Use in Transgene Expression Assays. Quinn PM, Buck TM, Ohonin C, Mikkers HMM, Wijnholds J. Methods Mol Biol. 2018;1715:261-273. doi: 10.1007/978-1-4939-7522-8_19. PMID: 29188520

Thesis

The Retinal Crumbs Complex: From Animal Models and Retinal Organoids to Therapy. Quinn PMJ. Leiden University. 2019 May 15. (PhD thesis)